Overview
SCIENTIFIC SCORE
Moderately Effective
Based on 20 Researches
8.3
USERS' SCORE
Good
Based on 22 Reviews
8.7
Supplement Facts
Serving Size: 1 Capsule
Serving Per Container: 30
Amount Per Serving
%DV
Ultimate Care Probiotic Culture Blend 100 Billion CFU
301 mg
***
Bifido Probiotic BlendBifidobacterium lactis BI-04®, Bifidobacterium lactis HN019™, Bifidobacterium infantis Bi-26™, Bifidobacterium lactis Bi-07®
54 Billion CFU
Lacto Probiotic BlendLactobacillus plantarum Lp-115®, Lactobacillus rhamnosus GG, Lactococcus lactis LI-23™, Lactobacillus casei Lc-11®, Lactobacillus paracasei Lpc-37®, Lactobacillus acidophilus La-14®, Lactobacillus acidophilus NCFM®, Lactobacillus brevis Lbr-35™
46 Billion CFU
Top Medical Research Studies
9
We explored how Lactobacillus acidophilus ATCC 4356 impacts yeast infections caused by Candida albicans. The study used both in vitro and in vivo models, with tests on biofilm formation and filamentation in lab settings and survival analysis in Galleria mellonella larvae.
Our findings revealed that L. acidophilus was effective in inhibiting C. albicans biofilm and filament formation in vitro. Additionally, the injections into infected larvae significantly improved their survival rates and reduced yeast counts compared to a control group. Overall, L. acidophilus demonstrated promising protective effects against yeast infections.
Our findings revealed that L. acidophilus was effective in inhibiting C. albicans biofilm and filament formation in vitro. Additionally, the injections into infected larvae significantly improved their survival rates and reduced yeast counts compared to a control group. Overall, L. acidophilus demonstrated promising protective effects against yeast infections.
Read More
9
This study examined how Lactobacillus rhamnosus could impact the development of yeast infections, specifically candidiasis. By using immunosuppressed mice, we created various groups to see if taking this probiotic before or during Candida exposure made a difference.
The results were promising: the group that took the probiotic 14 days beforehand showed significantly lower levels of Candida. We also noted reduced inflammation in tissues from these mice. While some cytokine levels were lower across the board, the differences weren't statistically significant. Overall, lactobacillus rhamnosus appears to be a potentially effective preventive measure against yeast infections.
The results were promising: the group that took the probiotic 14 days beforehand showed significantly lower levels of Candida. We also noted reduced inflammation in tissues from these mice. While some cytokine levels were lower across the board, the differences weren't statistically significant. Overall, lactobacillus rhamnosus appears to be a potentially effective preventive measure against yeast infections.
Read More
8
Probiotics inhibit Candida biofilm growth
We investigated how probiotics, particularly Lactobacillus acidophilus and its relatives, affect the development of Candida albicans biofilms. Our findings revealed that these probiotics notably decreased biofilm growth and altered the yeast's growth behavior.
Specifically, Lactobacillus rhamnosus effectively diminished early biofilm stages. However, it didn't significantly influence mature biofilms. Overall, the lactobacilli hindered the transition of Candida from yeast to fungal forms and reduced its ability to form biofilms.
This research highlights the potential of using probiotics as a supportive treatment for yeast infections.
Specifically, Lactobacillus rhamnosus effectively diminished early biofilm stages. However, it didn't significantly influence mature biofilms. Overall, the lactobacilli hindered the transition of Candida from yeast to fungal forms and reduced its ability to form biofilms.
This research highlights the potential of using probiotics as a supportive treatment for yeast infections.
Read More
Most Useful Reviews
9
Chronic issues resolved
124 people found this helpful
I've suffered from chronic yeast infections for the past year and a half, particularly after becoming sexually active. The routine of battling infections was exhausting. Recently, I started taking this product, and within just one week, I felt like a complete change had occurred. The yeast infection I was struggling with cleared with over-the-counter medicine, and I feel much healthier now!
Read More
9
Finally found relief
37 people found this helpful
Worth all the hype! A friend recommended these to tackle my chronic BV issue. After starting to take them daily, I've noticed no further symptoms of BV, which is remarkable. I used to depend on boric acid suppositories, but thankfully I've been able to stop using them since starting these probiotics. If you're desperate for a solution, you must try this product!
Read More
9
Immediate relief
29 people found this helpful
This probiotic is incredible! I felt a yeast infection beginning postpartum and couldn't visit my OB due to time constraints. I researched probiotics and found one with effective strains for treating yeast infections. I ordered it, took it immediately, and within an hour, the itching and burning sensations calmed significantly. I plan to continue taking it for prevention.
Read More
Medical Researches
SCIENTIFIC SCORE
Moderately Effective
Based on 20 Researches
8.3
- All Researches
9.5
We investigated how Lactobacillus rhamnosus Lcr35, contained in the GYNOPHILUS product, can combat yeast infections like Candida. This study showed that the product’s formulation, enhanced by sodium thiosulfate, improves its ability to kill yeast cells.
Remarkably, after 48 hours of co-culturing, the yeast’s viability dropped to zero. The presence of odor-active sulfur compounds, specifically S-methyl thioacetate, was linked to this antifungal effect.
Interestingly, achieving the full antifungal impact relies on these sulfur components.
Remarkably, after 48 hours of co-culturing, the yeast’s viability dropped to zero. The presence of odor-active sulfur compounds, specifically S-methyl thioacetate, was linked to this antifungal effect.
Interestingly, achieving the full antifungal impact relies on these sulfur components.
Read More
9
We examined how a combination of ultra-low-dose estriol and lactobacilli affects vaginal health in postmenopausal women dealing with severe atrophic vaginitis while on aromatase inhibitors. Over 28 days, 16 breast cancer survivors used Gynoflor®, improving their vaginal flora. Remarkably, the lactobacillary grades increased significantly, alongside reductions in inflammatory markers like leukocytes and parabasal cells.
Although we observed a temporary spike in Candida colonization, it quickly returned to normal levels. Overall, these findings suggest that this treatment can effectively enhance vaginal health while being safe for women facing similar challenges.
Although we observed a temporary spike in Candida colonization, it quickly returned to normal levels. Overall, these findings suggest that this treatment can effectively enhance vaginal health while being safe for women facing similar challenges.
Read More
9
We explored how Lactobacillus acidophilus ATCC 4356 impacts yeast infections caused by Candida albicans. The study used both in vitro and in vivo models, with tests on biofilm formation and filamentation in lab settings and survival analysis in Galleria mellonella larvae.
Our findings revealed that L. acidophilus was effective in inhibiting C. albicans biofilm and filament formation in vitro. Additionally, the injections into infected larvae significantly improved their survival rates and reduced yeast counts compared to a control group. Overall, L. acidophilus demonstrated promising protective effects against yeast infections.
Our findings revealed that L. acidophilus was effective in inhibiting C. albicans biofilm and filament formation in vitro. Additionally, the injections into infected larvae significantly improved their survival rates and reduced yeast counts compared to a control group. Overall, L. acidophilus demonstrated promising protective effects against yeast infections.
Read More
9
We examined the effectiveness of various Lactobacillus strains, particularly Lactobacillus rhamnosus, against yeast infections caused by Candida. Through our analysis, we found that live probiotic cells and their cell-free supernatants showed strong anticandidal activity.
Notably, L. rhamnosus SD11 was especially effective, particularly when supplemented with prebiotics like mangosteen, leading to improved growth and metabolic activity. This suggests that combining probiotics and prebiotics might be a promising alternative treatment for Candida infections.
Notably, L. rhamnosus SD11 was especially effective, particularly when supplemented with prebiotics like mangosteen, leading to improved growth and metabolic activity. This suggests that combining probiotics and prebiotics might be a promising alternative treatment for Candida infections.
Read More
9
Probiotic shows potential against fungus
We investigated the effectiveness of Lactobacillus rhamnosus Lcr35® against Candida albicans using lab models. The study showed that this probiotic significantly reduced fungal growth and adhesion in cell cultures.
In the nematode model, it helped improve worm survival rates, even against detectable yeast. The probiotic appeared to suppress the fungus's virulence while also activating the worm's immune responses. Overall, the findings suggest that Lcr35® could be a promising strategy for combatting yeast infections.
In the nematode model, it helped improve worm survival rates, even against detectable yeast. The probiotic appeared to suppress the fungus's virulence while also activating the worm's immune responses. Overall, the findings suggest that Lcr35® could be a promising strategy for combatting yeast infections.
Read More
User Reviews
USERS' SCORE
Good
Based on 22 Reviews
8.7
- All Reviews
- Positive Reviews
- Negative Reviews
9
Chronic issues resolved
124 people found this helpful
I've suffered from chronic yeast infections for the past year and a half, particularly after becoming sexually active. The routine of battling infections was exhausting. Recently, I started taking this product, and within just one week, I felt like a complete change had occurred. The yeast infection I was struggling with cleared with over-the-counter medicine, and I feel much healthier now!
Read More
9
Finally found relief
37 people found this helpful
Worth all the hype! A friend recommended these to tackle my chronic BV issue. After starting to take them daily, I've noticed no further symptoms of BV, which is remarkable. I used to depend on boric acid suppositories, but thankfully I've been able to stop using them since starting these probiotics. If you're desperate for a solution, you must try this product!
Read More
9
Immediate relief
29 people found this helpful
This probiotic is incredible! I felt a yeast infection beginning postpartum and couldn't visit my OB due to time constraints. I researched probiotics and found one with effective strains for treating yeast infections. I ordered it, took it immediately, and within an hour, the itching and burning sensations calmed significantly. I plan to continue taking it for prevention.
Read More
9
Reduced infection frequency
26 people found this helpful
I've truly noticed a reduction in yeast infections since I began taking these pills. They contain the top two probiotic strains essential for vaginal health. After suffering frequent UTIs that necessitated antibiotics, I began taking these probiotics, and now I feel almost normal again after three months. I even occasionally use them internally to help maintain my good bacteria levels.
Read More
7.5
No more side effects
15 people found this helpful
I was recently prescribed Jardiance for diabetes, which can cause vaginal yeast infections. After suffering through three infections in a month, I researched essential probiotics that prevent these infections and found this product. I’ve been taking it for a month now, and I've seen a significant decrease in the side effects from my medication. I recommend this probiotic to any woman experiencing excessive yeast infections.
Read More
Frequently Asked Questions
8
Probiotics inhibit Candida biofilm growth
We investigated how probiotics, particularly Lactobacillus acidophilus and its relatives, affect the development of Candida albicans biofilms. Our findings revealed that these probiotics notably decreased biofilm growth and altered the yeast's growth behavior.
Specifically, Lactobacillus rhamnosus effectively diminished early biofilm stages. However, it didn't significantly influence mature biofilms. Overall, the lactobacilli hindered the transition of Candida from yeast to fungal forms and reduced its ability to form biofilms.
This research highlights the potential of using probiotics as a supportive treatment for yeast infections.
Specifically, Lactobacillus rhamnosus effectively diminished early biofilm stages. However, it didn't significantly influence mature biofilms. Overall, the lactobacilli hindered the transition of Candida from yeast to fungal forms and reduced its ability to form biofilms.
This research highlights the potential of using probiotics as a supportive treatment for yeast infections.
8
We examined the impacts of combining standard azole therapy with a local probiotic treatment to combat recurrent yeast infections. Involving 436 women, we divided participants into two groups: one receiving standard azole treatment alone and the other receiving the same treatment along with Lactobacillus acidophilus probiotics.
The results were telling. While over 79% of women in the azole-only group experienced lingering symptoms, those in the probiotic group saw this drop to just 31%. Additionally, microbiological success rates improved significantly, indicating that probiotics enhance the effectiveness of conventional treatments for vaginal Candida infections.
The results were telling. While over 79% of women in the azole-only group experienced lingering symptoms, those in the probiotic group saw this drop to just 31%. Additionally, microbiological success rates improved significantly, indicating that probiotics enhance the effectiveness of conventional treatments for vaginal Candida infections.
9
Potential ally against Candida infections
We explored how Lactobacillus rhamnosus (LR) can aid in fighting Candida infections. The study tested LR and other lactobacilli in both mouse macrophages and Galleria mellonella larvae.
Results showed that LR significantly boosted immune responses and enhanced larvae survival against Candida. In particular, it reduced yeast counts, showcasing its potential as an adjunct treatment for managing yeast infections.
Ultimately, LR stood out for its anti-Candida effects, making it a promising ally against these tough fungal threats.
Results showed that LR significantly boosted immune responses and enhanced larvae survival against Candida. In particular, it reduced yeast counts, showcasing its potential as an adjunct treatment for managing yeast infections.
Ultimately, LR stood out for its anti-Candida effects, making it a promising ally against these tough fungal threats.
7
We examined a series of studies focusing on the effects of Lactobacillus probiotics against Candida species, which cause yeast infections affecting many adult women. Reviewing 15 articles from 2015 to 2020, we noticed that particular strains like L. acidophilus can inhibit Candida growth.
Extended use of these probiotics seems to improve treatment outcomes, especially when combined with traditional medications. Our findings suggest that the combination of the right Lactobacillus strain and duration of use plays a crucial role in tackling these stubborn infections.
Extended use of these probiotics seems to improve treatment outcomes, especially when combined with traditional medications. Our findings suggest that the combination of the right Lactobacillus strain and duration of use plays a crucial role in tackling these stubborn infections.
References
- Pimentel MMNSC, de Carvalho Alves J, Pinheiro LHS, Roselino MN. Potential Action of Probiotics Against Fungi of the Genus : A Bibliographic Review. Recent Pat Biotechnol. 2023;17:198. doi:10.2174/1872208317666221027093644
- Spaggiari L, Sala A, Ardizzoni A, De Seta F, Singh DK, et al. Lactobacillus acidophilus, L. plantarum, L. rhamnosus, and L. reuteri Cell-Free Supernatants Inhibit Candida parapsilosis Pathogenic Potential upon Infection of Vaginal Epithelial Cells Monolayer and in a Transwell Coculture System . Microbiol Spectr. 2022;10:e0269621. doi:10.1128/spectrum.02696-21
- Er S, İstanbullu Tosun A, Arık G, Kıvanç M. Anticandidal activities of lactic acid bacteria isolated from the vagina. Turk J Med Sci. 2019;49:375. doi:10.3906/sag-1709-143
- Mezzasalma V, Manfrini E, Ferri E, Boccarusso M, Di Gennaro P, et al. Orally administered multispecies probiotic formulations to prevent uro-genital infections: a randomized placebo-controlled pilot study. Arch Gynecol Obstet. 2017;295:163. doi:10.1007/s00404-016-4235-2
- Matsubara VH, Wang Y, Bandara HMHN, Mayer MPA, Samaranayake LP. Probiotic lactobacilli inhibit early stages of Candida albicans biofilm development by reducing their growth, cell adhesion, and filamentation. Appl Microbiol Biotechnol. 2016;100:6415. doi:10.1007/s00253-016-7527-3
- Donders G, Bellen G, Neven P, Grob P, Prasauskas V, et al. Effect of ultra-low-dose estriol and lactobacilli vaginal tablets (Gynoflor®) on inflammatory and infectious markers of the vaginal ecosystem in postmenopausal women with breast cancer on aromatase inhibitors. Eur J Clin Microbiol Infect Dis. 2015;34:2023. doi:10.1007/s10096-015-2447-1
- Vilela SF, Barbosa JO, Rossoni RD, Santos JD, Prata MC, et al. Lactobacillus acidophilus ATCC 4356 inhibits biofilm formation by C. albicans and attenuates the experimental candidiasis in Galleria mellonella. Virulence. 2015;6:29. doi:10.4161/21505594.2014.981486
- Kovachev SM, Vatcheva-Dobrevska RS. Local Probiotic Therapy for Vaginal Candida albicans Infections. Probiotics Antimicrob Proteins. 2015;7:38. doi:10.1007/s12602-014-9176-0
- Ishikawa KH, Mayer MP, Miyazima TY, Matsubara VH, Silva EG, et al. A multispecies probiotic reduces oral Candida colonization in denture wearers. J Prosthodont. 2015;24:194. doi:10.1111/jopr.12198
- Chantanawilas P, Pahumunto N, Thananimit S, Teanpaisan R. Anticandidal Activity of Various Probiotic Lactobacillus Strains and Their Efficacy Enhanced by Prebiotic Supplementation. Curr Microbiol. 2024;81:271. doi:10.1007/s00284-024-03800-y
- Dausset C, Bornes S, Miquel S, Kondjoyan N, Angenieux M, et al. Identification of sulfur components enhancing the anti-Candida effect of Lactobacillus rhamnosus Lcr35. Sci Rep. 2020;10:17074. doi:10.1038/s41598-020-74027-7
- Kumherová M, Veselá K, Kosová M, Mašata J, Horáčková Š, et al. Novel Potential Probiotic Lactobacilli for Prevention and Treatment of Vulvovaginal Infections. Probiotics Antimicrob Proteins. 2021;13:163. doi:10.1007/s12602-020-09675-2
- Poupet C, Saraoui T, Veisseire P, Bonnet M, Dausset C, et al. Lactobacillus rhamnosus Lcr35 as an effective treatment for preventing Candida albicans infection in the invertebrate model Caenorhabditis elegans: First mechanistic insights. PLoS One. 2019;14:e0216184. doi:10.1371/journal.pone.0216184
- Lee X, Vergara C, Lozano CP. Severity of Candida-associated denture stomatitis is improved in institutionalized elders who consume Lactobacillus rhamnosus SP1. Aust Dent J. 2019;64:229. doi:10.1111/adj.12692
- De Gregorio PR, Silva JA, Marchesi A, Nader-Macías MEF. Anti-Candida activity of beneficial vaginal lactobacilli in in vitro assays and in a murine experimental model. FEMS Yeast Res. 2019;19. doi:10.1093/femsyr/foz008
- Leão MVP, Tavares TAA, Gonçalves E Silva CR, Dos Santos SSF, Junqueira JC, et al. Lactobacillus rhamnosus intake can prevent the development of Candidiasis. Clin Oral Investig. 2018;22:2511. doi:10.1007/s00784-018-2347-8
- Rossoni RD, Dos Santos Velloso M, Figueiredo LMA, Martins CP, Jorge AOC, et al. Clinical strains of Lactobacillus reduce the filamentation of Candida albicans and protect Galleria mellonella against experimental candidiasis. Folia Microbiol (Praha). 2018;63:307. doi:10.1007/s12223-017-0569-9
- Tan Y, Leonhard M, Moser D, Ma S, Schneider-Stickler B. Inhibitory effect of probiotic lactobacilli supernatants on single and mixed non-albicans Candida species biofilm. Arch Oral Biol. 2018;85:40. doi:10.1016/j.archoralbio.2017.10.002
- Mailänder-Sánchez D, Braunsdorf C, Grumaz C, Müller C, Lorenz S, et al. Antifungal defense of probiotic Lactobacillus rhamnosus GG is mediated by blocking adhesion and nutrient depletion. PLoS One. 2017;12:e0184438. doi:10.1371/journal.pone.0184438
- de Oliveira FE, Rossoni RD, de Barros PP, Begnini BE, Junqueira JC, et al. Immunomodulatory effects and anti-Candida activity of lactobacilli in macrophages and in invertebrate model of Galleria mellonella. Microb Pathog. 2017;110:603. doi:10.1016/j.micpath.2017.08.006
